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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Gene expression profiling of chondrogenic differentiation by dexamethasone-conjugated polyethyleneimine with SOX trio genes in stem cells

Fig. 5

The mRNA expression level of differentiation-related genes in transfected hMSCs. a Pie chart of the microarray data show that SOX9 and COLII were upregulated and MMP3 and COLI were downregulated in hMSCs. b RT-PCR analysis of chondrogenesis-related markers. The hMSCs transfected with nothing (panel a), DEX/PEI only (panel b), SOX5- complexed DEX/PEI (panel c), SOX6-complexed DEX/PEI (panel d), SOX9-complexed DEX/PEI (panel e), and SOX5/6/9 (trio) conjugated DEX/PEI (DI-NPs) (panel f). c Heatmap showing the expression of COL1A1, COL1A2, Aggrecan (ACAN), COMP, and SOX9 in each group of hMSCs relative to nontreated hMSCs (panel a). Log2 fold-changes in the expression of SOX9 and COMP in each group of hMSCs relative to that in nontreated hMSCs (panel b). n = 5. COL collagen

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Stem Cell Research & Therapy

ISSN: 1757-6512