Fig. 7
From: An integrated toolkit for human microglia functional genomics
A web-accessible platform showcasing graphical visualization of the multi-omic data from iMG model system. A. Depicts how the web portal displays the K-means clustering of ~ 2000 single-cell transcriptional profiles from iMG. B. Displays, as an example the expression of TREM2 gene in all four identified K-means clusters. C. Web-platform offers user-defined visualization of average, log-transformed expression of multiple genes. Depicted are 10 microglial gens, grouped by categorical cell information (i.e. cluster identity). D-E. Show ATAC-Seq data browsing in the UCSC genome browser, demonstrating density plots around AD-linked genes SPI1 (D) and PICALM (E) in iMG (top three tracks) and pMG (bottom track). F. Demonstrates comparative abundance of microglial proteins in iMG and pMG using mass spectrometry data, displayed after normalizing individual protein abundances by the sum of all abundances