Fig. 6

Characteristics of gene expression regulated by L-ELK1 and S-ELK1. A A heatmap showing the expression level of neutrophil activity-related genes regulated by L-ELK1 and S-ELK1. B A heatmap showing the expression level of hypoxia- and oxidative stress-related genes regulated by L-ELK1 and S-ELK1. C Bar plots showing the effect of L-ELK1 and S-ELK1 on the expression of peptidyl-tyrosine phosphorylation (GO:0050730)-related genes. All the expression levels of genes are shown in CPM (counts per million) value derived from RNA-Seq data. D A heatmap showing both L-ELK1 and S-ELK1 downregulated genes that negatively regulate phosphorylation (GO:0001933) and positively regulate DNA-binding transcription factor activity (GO:0051090). E A bar plot showing the expression value (log2 RMA (Robust Multiarray Average) value detected by Gene Array Scanner (Affymetrix)) of ELK1 in different AML subclasses from the public dataset (GDS1064). F A schematic plot showing the global impact of overexpression ELK1 on hematopoiesis